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Prof Adrian Thrasher

Professor in Paediatric Immunology


• Primary immunology 
• Gene Therapy  

• Wiskott-Aldrich Syndrome 
• Disorder of innate immunity 
• Autoimmune Lymphoproliferative Syndrome 

• MBBS St George’s Hospital Medical School, University of London 
• FBS 
• PhD in biochemisty from the University of London 
• FMedSci 
• FRCPath 
• Elected Fellow of the Society of Biology, 2011 
• President British Society for Gene Therapy (BSGT) 2010- 
• Elected member of the Board of Directors, American Society of Gene Therapy, May 2006 –2009 
• Elected member of the Henry Kunkel Society, March 2006- 
• Elected Fellow of The Academy of Medical Sciences, 2005- 

• Pathophysiology of primary immunodeficiency syndromes especially WAS 
• The actin cytoskeleton in haematopoietic cells 
• The development of somatic gene therapy 
• Thymus transplantation 


News & Publications

Adrian Thrasher has over 200 peer-reviewed publications including: 
Kohn, D. B., Shaw, K. L., Sokolic, R., Carbonaro, D. A., Davila, A., Barman, P., . . . Candotti, F. 2015. Autologous Transplant/Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immune Deficiency. Biology of Blood and Marrow Transplantation, 21 (2), S102. 
Sanber, K. S., Knight, S. B., Stephen, S. L., Bailey, R., Escors, D., Collins, M. K., . . . Minshull, J. 2015. Construction of stable packaging cell lines for clinical lentiviral vector production. Scientific Reports, 5. 
Qasim, W., Brunetto, M., Gehring, A. J., Xue, S. A., Schurich, A., Khakpoor, A., . . . Bertoletti, A. 2015. Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. J Hepatol, 62 (2) pp. 486-491. 
Hacein-Bey Abina, S., Blondeau, J., Caccavelli, L., Touzot, F., Lefrère, F., Magalon, J., . . . Bushman, F. D. 2015. Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndrome. JAMA - Journal of the American Medical Association, 313 (15) pp. 1550-1563. 
Carmo, M., Montiel-Equihua, C. A., Alonso-Ferrero, M. E., Blundell, M. P., Thrasher, A. J., Gaspar, H. B., . . . Baum, C. 2015. Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency. Molecular Therapy, 23 (4) pp. 737-745. 
Carmo, M., Risma, K. A., Arumugam, P., Tiwari, S., Hontz, A. E., Montiel-Equihua, C. A., . . . Gaspar, H. B. 2015. Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency. Mol Ther, 23 (4), pp. 737-745. 
Shaw, S. W., Blundell, M. P., Pipino, C., Shangaris, P., Maghsoudlou, P., Ramachandra, D. L., . . . de Coppi, P. 2015. Sheep CD34+ amniotic fluid cells have hematopoietic potential and engraft after autologous in utero transplantation. Stem Cells, 33 (1), pp. 122-132. 
Navarro, J. -. M., Pradel, L. C., Loosveld, M., Fenouil, R., Maqbool, M. A., Morgado, E., . . . Ifrah, N. 2015. Site- and allele-specific polycomb dysregulation in T-cell leukaemia. Nature Communications, 6. 
Vijayakumar, V., Monypenny, J., Chen, X. J., Jones, G. E., Machesky, L. M., Lilla, S., . . . Calle, Y. 2015. Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Journal of Cell Science, 128 (2) pp. 251-265. 
Qasim, W., Gaspar, H. B., & Thrasher, A. J. 2014. "Darwinian" tumor-suppression model unsupported in clinical experience. Mol Ther, 22 (9) pp. 1562-1563. 

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