Dr Reem Elfeky
Overview
Reem Elefeky is paediatric Immunologist/bone marrow transplant specialist with special interest in cell and gene therapy.
She is currently a consultant in Paediatric Immunology, Great Ormond Street Hospital, London, UK. She graduated from Ain Shams University in Egypt in 2001 and then trained in Paediatrics. She subsequently obtained a masters and doctorate degrees in paediatric immunology. In 2013, Dr Elefeky secured a clinical fellowship at GNCH, Newcastle UK and in 2014 moved to clinical post at GOSH.
In 2020, She was have been awarded M.D(Res) in BMT/Immunology, UCL London 2020 after coordinating a first in human trial in haploidentical transplantation using genetically modified T cells.
She has published over 26 original articles, including as lead authors and in high impact journals such as JACI, Blood & Science Immunology.
She presents Sher research at major scientific meetings, most recently in EBMT 2022, 2020, 2019, ESID 2020, EBMT 2018, ASH 2018 and ESID 2018 where have received 2 best poster prizes and 2 travel awards.
Dr Elefeky also recently won She John Goldman prize for best clinical research in BSBMT 2019. She has been an ESID mentor since 2019; training European doctors to develop a career in immunology and a member of UK/Ireland task force for developing BMT services across the UK.
Besides Sher work in the UK, She is an active member of the African society of immune deficiency. She is the copy editor of the African society of immune deficiency (ASID) newsletter since 2013 and have been elected twice.
In 2017 and 2019 She was a board member of ASID for research, teaching and education and has also created a teaching program for African non-immunologist in IEI and actively participated in A-projects- in collaboration with IPOPI organisation- directed to clinicians and nurses working with IEI patients. This includes training on immunoglobulin therapy, management of complications related to PID and when to refer to bone marrow transplant.
She also won an ESID 2018 best E-poster prize in recognition of Sher work in ASID. She work closely with ESID in creating ASID schools for immunology to train future doctors in immunology; Latest school on B cell defect was in Sep 2021.
Dr Elefeky is also a member of different international organisations and work consistently with IPOPI and JMF societies that aim in delivering best service to patients with IEI.
Credentials
Paediatric immunology
Severe combined immune deficiency
MHC class II
Combined immune deficiency
Common variable immune defect
Chronic granulomatous disease
HyperIgE syndromes
Gut disease associated with primary immune defect
Familial haemophagocytic lymphohistiocytosis
Cell therapy
Stem cell transplant for patients with primary immune deficiency
Long term follow-up post- stem cell transplant for patients with primary immune deficiency
Qualifications:
MD(Res) in immunology/BMT, ICH, UCL; March 2020
Thesis: Donor T cells with inducible caspase safety switch following haploidentical transplants.
Master’s degree in Paediatrics [Ain Shams University]; February 2006.
Thesis: Changes in the splanchnic circulation in neonates as a predictor of early onset neonatal sepsis.
PhD in Paediatrics [Ain Shams University]; January 2010.
Thesis: Immunogenicity of hepatitis B vaccine in patients with connective tissue disease.
Membership:
- Member of the Royal College of physicians and Child health (RCPCH).
- Member of European Society of Immune deficiency (ESID).
- Member of Egyptian Society of Paediatric Allergy and Immunology (ESPAI).
- Member of the African society of immune deficiency (ASID).
- Copyeditor of the ASID newsletter since February 2014.
- ASID board member-clinical training; since October 2017-April 2019.
- ASID research committee/office head; since April 2019-ongoing.
Improving stem cell transplant outcome for patients with primary immune deficiency
Novel therapies for primary immune deficiencies
News & Publications
- Svec P, Elfeky R, Galimard JE, Higham CS, Dalissier A, Quigg TC, Bueno Sanchez D, Han Lum S, Faraci M, Cole T, Pichler H, Benítez-Carabante MI, Horakova J, Gonzalez-Vicent M, Yanir A, Fagioli F, Wölfl M, von der Weid N, Protheroe R, Krivan G, Speckmann C, James B, Avcin SL, Bertrand Y, Verna M, Riha P, Patrick K, Cesaro S, Kalwak K, Bierings M, Büchner J, Mellgren K, Prohászka Z, Neven B, Lankester A, Corbacioglu S. Use of eculizumab in children with allogeneic haematopoietic stem cell transplantation associated thrombotic microangiopathy - a multicentre retrospective PDWP and IEWP EBMT study. Bone Marrow Transplant. 2022 Nov 4.
- Day J, Elfeky R, Nicholson B, Goodman R, Pearce R, Fox TA, Worth A, Booth C, Veys P, Carpenter B, Hough R, Gaspar HB, Titman P, Ridout D, Workman S, Hernandes F, Sandford K, Laurence A, Campbell M, Burn SB, Morris E. Retrospective, landmark analysis of long-term adult morbidity following allogeneic HSCT for inborn errors of immunity in infancy and childhood. Accepted April 2022 in Journal of Clinical Immunology.
- Maimaris J, Wagner T, Bowcock S, Elfeky R. Incidental Finding of Muscle Lymphoma in an Adult with Common Variable Immune Deficiency. Clin Image Case Rep J. 2022 March; 4(2): 218.
- Magnani A, Semeraro M, Adam F, Booth C, Dupré L, Morris EC, Gabrion A, Roudaut C, Borgel D, Toubert A, Clave E, Abdo C, Gorochov G, Petermann R, Guiot M, Miyara M, Moshous D, Magrin E, Denis A, Suarez F, Lagresle C, Roche AM, Everett J, Trinquand A, Guisset M, Bayford JX, Hacein-Bey-Abina S, Kauskot A, Elfeky R, et al. Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott-Aldrich syndrome. Nat Med. 2022 Jan;28(1):71-80.
- Haimel M, Pazmandi J, Heredia RJ, Dmytrus J, Bal SK, Zoghi S, van Daele P, Briggs TA, Wouters C, Bader-Meunier B, Aeschlimann FA, Caorsi R, Eleftheriou D, Hoppenreijs E, Salzer E, Bakhtiar S, Derfalvi B, Saettini F, Kusters MAA, Elfeky R, et al. Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity. J Allergy Clin Immunol. 2022 Jan;149(1):369-378.
- Steininger J, Leiss-Piller A, Geier CB, Rossmanith R, Elfeky R, Bra D, Pichler H, Lawitsch N, et al. A novel IL2RG frame-restoring rescue mutation mimics early T cell engraftment following haploidentical hematopoietic stem cell transplantation in a patient with X- SCID. Front. Pediatr, March 2021.
- Elfeky R, Lazareva A, Qasim W, Veys P. Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources. Expert Rev Clin Immunol. 2019 May 9:1-17.
- Elfeky R, Shah RM, Unni MNM, Ottaviano G, Rao K, Chiesa R, Amrolia P, Worth A, Flood T, Abinun M, et al. New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies. J Allergy Clin Immunol. 2019 Jul;144(1):280-293.
- Elfeky R, Furtado-Silva JM, Chiesa R, Rao K, Amrolia P, Lucchini G, Gilmour K, Adams S, Bibi S, Worth A, et al. 100% survival after transplantation of 34 Wiskott Aldrich Syndrome patients over 20 years. J Allergy Clin Immunol, 2018 Nov;142(5):1654-1656.
- Elfeky RA, Furtado-Silva JM, Chiesa R, Rao K, Lucchini G, Amrolia P, Worth A, Gaspar B, Qasim W, Veys P. Umbilical cord blood transplantation without in vivo T-cell depletion for children with MHC class II deficiency. J Allergy Clin Immunol. 2018 Jan 20.
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