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菲利普·安克利夫 医生

血液病专家医师
菲利普·安克利夫医生

概述

菲利普·安克利夫医生是一位经验丰富的小儿血液病专家(自2003年起就职于大奥蒙德街儿童医院) ,在所有恶性血液病学领域都有广泛的实践经验。他的研究范围从白血病发病机理的基础科学,到优化主流治疗方法到新颖的免疫治疗方法。他在严重的先天性中性粒细胞减少症和骨髓衰竭方面也有专长。安克利夫医生也是英国国家癌症研究所儿童白血病研究组的主席。 

相关资质

  • 小儿白血病及相关疾病 

  • 重症先天性中性白细胞减少症

  • 骨髓衰竭综合征

  • 1987 – 1992 剑桥大学及Addenbrookes医院临床学校 

  • 1993- 1994 普通医疗训练,利兹总医院 

  • 1995-1999 血液病专家培训,伦敦大学学院医院及大奥蒙德街儿童医院 

  • 2000-2003 医学博士,伦敦大学学院,“先天性重度中性粒细胞减少症的发病机制”

  • 英国皇家内科医学院研究员

  • 英国皇家病理学院研究员

  • 英国国家癌症研究所 - 儿童白血病分组骨髓和淋巴研究工作组的长期成员,现任此小组主席 

  • 2006年国际婴儿急性淋巴细胞白血病治疗方案国家协调员 

  • UKALL R3试验-复发性急性淋巴细胞白血病的国际协议协调员 

  • MyeChild 01国际急性髓系白血病儿童III期临床试验与吉妥珠单抗Ozogamicin的剂量发现研究的联合研究者 

  • 基因组学英国临床阐释合作组干细胞和骨髓疾病小组成员

  • ​​​​​​2017年 - 婴幼儿正常骨髓免疫表型特征研究 
  • 2018年 - 儿童前体b系急性淋巴细胞白血病基因非分类亚型的分子遗传学和细胞遗传学特征 

  • 2016年 - 急性髓系白血病患儿的国际随机III期临床试验-结合吉妥珠单抗Ozogamicin联合诱导化疗的嵌入剂量发现研究

新闻和论文发表

MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia.  Germeshausen M, Ancliff P, Estrada J, Metzler M, Ponstingl E, Rütschle H, Schwabe D, Scott RH, Unal S, Wawer A, Zeller B, Ballmaier M. 

Blood Adv. 2018 Mar 27;2(6):586-596. 

Targeting acute myeloid leukemia by drug-induced c-MYB degradation.  Walf-Vorderwülbecke V, Pearce K, Brooks T, Hubank M, van den Heuvel-Eibrink MM, Zwaan CM, Adams S, Edwards D, Bartram J, Samarasinghe S, Ancliff P, Khwaja A, Goulden N, Williams G, de Boer J, Williams O. 

Leukemia. 2018 Apr;32(4):882-889 

Myelodysplasia and liver disease extend the spectrum of RTEL1 related telomeropathies. 

Cardoso SR, Ellison ACM, Walne AJ, Cassiman D, Raghavan M, Kishore B, Ancliff P, Rodríguez-Vigil C, Dobbels B, Rio-Machin A, Al Seraihi AFH, Pontikos N, Tummala H, Vulliamy T, Dokal I. 

Haematologica. 2017 Aug;102(8):e293-e296 

Stem cell transplantation in severe congenital neutropenia: an analysis from the European Society for Blood and Marrow Transplantation.  Fioredda F, Iacobelli S, van Biezen A, Gaspar B, Ancliff P, Donadieu J, Aljurf M, Peters C, Calvillo M, Matthes-Martin S, Morreale G, van 't Veer-Tazelaar N, de Wreede L, Al Seraihy A, Yesilipek A, Fischer A, Bierings M, Ozturk G, Smith O, Veys P, Ljungman P, Peffault de Latour R, Sánchez de Toledo Codina J, Or R, Ganser A, Afanasyev B, Wynn R, Kalwak K, Marsh J, Dufour C 

Blood. 2015 Oct 15;126(16):1885-92;  

Disease evolution and outcomes in familial AML with germline CEBPA mutations.  Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW, Treleaven J, Georgiades P, Uglow E, Asou N, Uike N, Debeljak M, Jazbec J, Ancliff P, Gale R, Thomas X, Mialou V, Döhner K, Bullinger L, Mueller B, Pabst T, Stelljes M, Schlegelberger B, Wozniak E, Iqbal S, Okosun J, Araf S, Frank AK, Lauridsen FB, Porse B, Nerlov C, Owen C, Dokal I, Gribben J, Smith M, Preudhomme C, Chelala C, Cavenagh J, Fitzgibbon J. 

Blood. 2015 Sep 3;126(10):1214-23 

Congenital acute megakaryoblastic leukemia. 

Bain BJ, Chakravorty S, Ancliff P. 

Am J Hematol. 2015 Oct;90(10):963.  

PAX5 alterations in genetically unclassified childhood Precursor B-cell acute lymphoblastic leukaemia. 

Stasevich I, Inglott S, Austin N, Chatters S, Chalker J, Addy D, Dryden C, Ancliff P, Ford A, Williams O, Kempski H. 

Br J Haematol. 2015 Jun 26.  

Nutritional status in children with Shwachman-diamond syndrome. 

Pichler J, Meyer R, Köglmeier J, Ancliff P, Shah N. 

Pancreas. 2015 May;44(4):590-5.  

Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial.  Masurekar AN, Parker CA, Shanyinde M, Moorman AV, Hancock JP, Sutton R, Ancliff PJ, Morgan M, Goulden NJ, Fraser C, Hoogerbrugge PM, Revesz T, Darbyshire PJ, Krishnan S, Love SB, Saha V.  

PLoS One. 2014 Oct 3;9(10) 

GATA2 mutations in sporadic and familial acute myeloid leukaemia patients with CEBPA mutations. 

Green CL, Tawana K, Hills RK, Bödör C, Fitzgibbon J, Inglott S, Ancliff P, Burnett AK, Linch DC, Gale RE. 

Br J Haematol. 2013 Jun;161(5):701-5. 

Squamous cell carcinoma in a child with Clericuzio-type poikiloderma with neutropenia.  Rodgers W, Ancliff P, Ponting CP, Sanchez-Pulido L, Burns S, Hayman M, Kimonis V, Sebire N, Bulstrode N, Harper JI. 

Br J Dermatol. 2013 Mar;168(3):665-7.  

Prevalence and predictors of anthracycline cardiotoxicity in children treated for acute myeloid leukaemia: retrospective cohort study in a single centre in the United Kingdom.  Temming P, Qureshi A, Hardt J, Leiper AD, Levitt G, Ancliff PJ, Webb DK. 

Pediatr Blood Cancer. 2011 Apr;56(4):625-30.  

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension. Bond J, Gale DP, Connor T, Adams S, de Boer J, Gascoyne DM, Williams O, Maxwell PH, Ancliff PJ. 

Blood. 2011 Mar 31;117(13):3699-701.  

Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Parker C, Waters R, Leighton C, Hancock J, Sutton R, Moorman AV, Ancliff P, Morgan M, Masurekar A, Goulden N, Green N, Révész T, Darbyshire P, Love S, Saha V.   

Lancet. 2010 Dec 11;376(9757):2009-17.  

Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.  Bateman CM, Colman SM, Chaplin T, Young BD, Eden TO, Bhakta M, Gratias EJ, van Wering ER, Cazzaniga G, Harrison CJ, Hain R, Ancliff P, Ford AM, Kearney L, Greaves M. 

Blood. 2010 Apr 29;115(17):3553-8.  

Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds. 

Smith BN, Ancliff PJ, Pizzey A, Khwaja A, Linch DC, Gale RE. 

Br J Haematol. 2009 Mar;144(5):762-70.  

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.  Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike-Overzet K, Chatters SJ, de Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von Kalle C, Gaspar HB, Thrasher AJ 

J Clin Invest. 2008 Sep;118(9):3143-50 

Initiating and tumor-propagating cells in TEL-AML1-associated childhood leukemia.  Hong D, Gupta R, Ancliff P, Atzberger A, Brown J, Soneji S, Green J, Colman S, Piacibello W, Buckle V, Tsuzuki S, Greaves M, Enver T 

Science 2008 Jan 18;319(5861):336-9 

Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ 

J Exp Med. 2007 Sep 3;204(9):2213-24 

Mutations in the SBDS gene in acquired aplastic anemia. 

Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ, Dror Y, Chanock SJ, Lansdorp PM, Young NS 

Blood. 2007 Aug 15;110(4):1141-6 

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. 

Menne TF, Goyenechea B, Sánchez-Puig N, Wong CC, Tonkin LM, Ancliff PJ, Brost RL, Costanzo M, Boone C, Warren AJ. 

Nat Genet. 2007 Apr;39(4):486-95 

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. 

Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ. 

Blood. 2006 Oct 1;108(7):2182-9 

Congenital neutropenia.  

Ancliff PJ. 

Blood Reviews. 2003 Dec;17(4):209-16 

Neutrophil elastase mutations in congenital neutropenia – genetics and potential mechanisms. 

Ancliff PJ, Gale RE, Linch DC 

Hematology. 2003 Jun; 8(3): 165-71 

Long-Term Follow-Up of G-CSF Receptor Mutations in Patients with Severe Congenital Neutropenia: Implications for Leukaemogenesis and Therapy. 

Ancliff PJ, Gale RE, Liesner R, Hann I & Linch DC 

British Journal of Haematology 2003, 120(4): 685-90 

Paternal Mosaicism Proves the Pathogenic Nature of Mutations in Neutrophil Elastase in Severe Congenital Neutropenia. 

Ancliff PJ, Gale RE, Liesner R, Hann IM, Strobel S & Linch DC 

Blood 2002; 100(2): 707-9 

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease.  

Ancliff PJ, Gale RE, Liesner R, Hann IM & Linch DC 

Blood 2001 Nov 1; 98(9): 2645-50

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