Dr Kanchan Rao
Overview
Dr Kanchan Rao has worked in Bone Marrow Transplant (BMT) department at Great Ormond Street Hospital (GOSH) for the last 20 years since 1999 and now she is the Speciality Lead. She has been part of the development of unrelated donor transplants, reduced-intensity transplants, cord blood transplants and more recently CAR-T cell therapies for high-risk lymphoid malignancies. Dr Kanchan Rao is the Chair of the UK/Ireland Paediatric BMT group and chairs monthly meetings discussing complicated cases nationally and internationally.
Dr Kanchan Rao is a member of the Hemophagocytic lymphohistiocytosis (HLH) multidisciplinary national group to discuss the management of complex patients with HLH. Dr Rao has a special interest in HLH which is one of her areas of research. She also has an interest in viral complications after BMT, especially Adenovirus. She has over 60 publications in peer-reviewed journals.
Languages Spoken:
- English
- Hindi
- Tamil
Credentials
- Haemophagocytic lymphohistiocytosis (HLH)
- BMT for non-malignant conditions
- Juvenile myelomonocytic leukaemia (JMML)
Dr Rao has a special interest in HLH which is one of her areas of research. She also has an interest in viral complications after BMT, especially Adenovirus.
- MBBS, MD, MNAMS, MRCPCH
- Member of the Inborn errors working party
- Member of Histiocyte Society
- Chair of the UK/Ireland Paediatric BMT Group
- Management of Adenoviral complications after BMT
- Use of universal CAR-T cells for the treatment of relapsed/refractory B cell Leukemias
News & Publications
Lankester AC, Neven B, Mahlaoui N, von Asmuth EG, Courteille V, Alligon M, Albert MH, Serra IB, Bader P, Balashov D, Beier R, Bertrand Y, Blanche S, Bordon V, Bredius RG, Cant A, Cavazzana M, Diaz-de-Heredia C, Dogu F, Ehlert K, Entz-Werle N, Fasth A, Ferrua F, Ferster A, Formankova R, Friedrich W, Gonzalez-Vicent M, Gozdzik J, Güngör T, Hoenig M, Ikinciogullari A, Kalwak K, Kansoy S, Kupesiz A, Lanfranchi A, Lindemans CA, Meisel R, Michel G, Miranda NA, Moraleda J, Moshous D, Pichler H, Rao K, Sedlacek P, Slatter M, Soncini E, Speckmann C, Sundin M, Toren A, Vettenranta K, Worth A, Yeşilipek MA, Zecca M, Porta F, Schulz A, Veys P, Fischer A, Gennery AR. Hematopoietic cell transplantation in severe combined immunodeficiency: the SCETIDE 2006-2014 European cohort
J Allergy and Clin Imm. 2021 Oct 27;S0091-6749(21)01629-8. doi: 10.1016/j.jaci.2021.10.017. Online ahead of print
Laberko A, Deordieva E, Krivan G, Goda V, Bhar S, Kawahara Y, Rao K, Worth A, McDermott DH, Balashov D, Maschan A, Shcherbina A. Multicenter Experience of Hematopoietic Stem Cell Transplantation in WHIM Syndrome. J Clin Immunol. 2021 Oct 26. doi: 10.1007/s10875-021-01155-8. Online ahead of print.
Escaron C, Ralph E, Bibi S, Visser J, Aricò M, Rao K, Veys P, Gilmour K. Diagnosis of HLH: two siblings, two distinct genetic causes. Clin Exp Immunol. 2021 Nov 30. Online ahead of print
Kreins AY, Velasco HF, Cheong KN, Rao K, Veys P, Worth A, Gaspar HB, Booth C.Kreins AY, et al. Long-Term Immune Recovery After Hematopoietic Stem Cell Transplantation for ADA Deficiency: a Single-Center Experience J Clin Immunol. 2021 Oct 16. doi: 10.1007/s10875-021-01145-w. Online ahead of print.
Cordoba S, Onuoha S, Thomas S, Pignataro DS, Hough R, Ghorashian S, Vora A, Bonney D, Veys P, Rao K, Lucchini G, Chiesa R, Chu J, Clark L, Fung MM, Smith K, Peticone C, Al-Hajj M, Baldan V, Ferrari M, Srivastava S, Jha R, Arce Vargas F, Duffy K, Day W, Virgo P, Wheeler L, Hancock J, Farzaneh F, Domning S, Zhang Y, Khokhar NZ, Peddareddigari VGR, Wynn R, Pule M, Amrolia PJ.Cordoba S, et al. CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial Nat Med. 2021 Oct;27(10):1797-1805. doi: 10.1038/s41591-021-01497-1. Epub 2021 Oct 12.
Arnold DE, Nofal R, Wakefield C, Lehmberg K, Wustrau K, Albert MH, Morris EC, Heimall JR, Bunin NJ, Kumar A, Jordan MB, Cole T, Choo S, Brettig T, Speckmann C, Ehl S, Salamonowicz M, Wahlstrom J, Rao K, Booth C, Worth A, Marsh RA.Arnold DE, et al. Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD. J Clin Immunol. 2021 Sep 29:1-10. doi: 10.1007/s10875-021-01103-6. Online ahead of print.
Ottaviano G, Achini-Gutzwiller F, Kalwak K, Lanino E, Faraci M, Rao K, Chiesa R, Amrolia P, Bonanomi S, Rovelli A, Veys P, Lankester A, Balduzzi A, Lucchini G.Impact of in Vivo Lymphodepletion on Outcome in Children with Nonmalignant Disorders Receiving Peripheral Blood Stem Cell Transplantation. Transplant Cell Ther. 2021 Aug 24:S2666-6367(21)01165-9. doi: 10.1016/j.jtct.2021.08.015. Online ahead of print.
Using Whole Genome Sequences to Investigate Adenovirus Outbreaks in a Hematopoietic Stem Cell Transplant Unit. Myers CE, Houldcroft CJ, Roy S, Margetts BK, Best T, Venturini C, Guerra-Assunção JA, Williams CA, Williams R, Dunn H, Hartley JC, Rao K, Rolfe KJ, Breuer J. Front Microbiol. 2021 Jul 2;12:667790
Dimitrova D, Nademi Z, Maccari ME, Ehl S, Uzel G, Tomoda T, Okano T, Imai K, Carpenter B, Ip W, Rao K, Worth AJJ, Laberko A, Mukhina A, Néven B, Moshous D, Speckmann C, Warnatz K, Wehr C, Abolhassani H, Aghamohammadi A, Bleesing JJ, Dara J, Dvorak CC, Ghosh S, Kang HJ, Markelj G, Modi A, Bayer DK, Notarangelo LD, Schulz A, Garcia-Prat M, Soler-Palacín P, Karakükcü M, Yilmaz E, Gambineri E, Menconi M, Masmas TN, Holm M, Bonfim C, Prando C, Hughes S, Jolles S, Morris EC, Kapoor N, Koltan S, Paneesha S, Steward C, Wynn R, Duffner U, Gennery AR, Lankester AC, Slatter M, Kanakry JA. International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome. JACI. 2021 May 24
Lum SH, Elfeky R, Achini FR, Margarit-Soler A, Cinicola B, Perez-Heras I, Nademi Z, Flood T, Cheetham T, Worth A, Qasim W, Amin R, Rao K, Chiesa R, Bredius RGM, Amrolia P, Abinun M, Hambleton S, Veys P, Gennery AR, Lankester A, Slatter M. Outcome of non-haematological autoimmunity after haematopoietic stem cell transplantation in children. J Clin Immunol. 2021 Jan;41(1):171-184
Silva JMF, Jones A, Sibson K, Bibi S, Jeggo P, Woodbine L, Ahsan G, Gilmour KC, Rao K, Chiesa R, Lucchini G, Veys P, Worth A, Amrolia PJ. Haematopoietic stem cell transplantation for DNA Ligase 1 deficiency. J Clin Immunol. 2021 Jan;41(1):238-242
Benjamin R, Graham C, Yallop D, Jozwik A, Mirci-Danicar OC, Lucchini G, Pinner D, Jain N, Kantarjian H, Boissel N, Maus MV, Frigault MJ, Baruchel A, Mohty M, Gianella-Borradori A, Binlich F, Balandraud S, Vitry F, Thomas E, Philippe A, Fouliard S, Dupouy S, Marchiq I, Almena-Carrasco M, Ferry N, Arnould S, Konto C, Veys P, Qasim W; K Rao as part of UCART19 group. Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies. Lancet. 2020 Dec 12;396(10266):1885-1894
Elfeky R, Lucchini G, Lum SH, Ottaviano G, Builes N, Nademi Z, Battersby A, Flood T, Owens S, Cant AJ, Young H, Greener S, Walsh P, Kavanagh D, Annavarapu S, Rao K, Amrolia P, Chiesa R, Worth A, Booth C, Skinner R, Doncheva B, Standing J, Gennery AR, Qasim W, Slatter M, Veys P. New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT. Blood Adv.2020 Jun 9;4(11):2418-2429
Matthias Felber 1 ,Colin G Steward 2 , Karim Kentouche 3 , Anders Fasth 4 , Robert F Wynn 5 , Ulrike Zeilhofer 1 , Veronika Haunerdinger 1 , Benjamin Volkmer 1 , Seraina Prader 1 , Bernd Gruhn 3 , Stephan Ehl 6 , Kai Lehmberg 7 , Daniel Müller 8 , Andrew R Gennery 9 , Michael H Albert 10 , Fabian Hauck 10 , Kanchan Rao 11 , Paul Veys 11 , Moustapha Hassan 12 , Arjan C Lankester 13 , Jana Pachlopnik Schmid 1 , Mathias M Hauri-Hohl 1 , Tayfun Güngör 1. Targeted busulfan-based reduced-intensity conditioning and HLA-matched HSCT cure hemophagocytic lymphohistiocytosis. Blood Adv 2020. May 12; 4(9):1998-2010
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