Helen Cross 教授
概述
拥有大英帝国官佐勋章 (OBE) 的Helen Cross教授是威尔士亲王儿童癫痫症主席和伦敦大学学院 (UCL) 大奥蒙德街儿童健康研究院、大奥蒙德街儿童医院（GOSH）和位于英国林菲尔德的青年癫痫慈善组织的儿科神经病学的名誉顾问。她从1990年开始在GOSH工作，并在2007年成为一名教授。2015年，基于一直以来在儿科癫痫领域的服务与贡献，她被授予大英帝国官佐勋章(OBE)。
Cross教授一直担任儿童癫痫手术服务中心的临床顾问以及儿童药物研究网络神经科学临床研究小组的主席（自2012年至今）。她也是2013年负责国家健康与护理研究所针对癫痫方面指导方针证据更新的主席，并在2013至2017年期间当选为国际抗癫痫联盟的秘书长。
Cross教授针对经过手术切除治疗癫痫的患儿的癫痫发作，神经心理和行为结果广泛发表了学术文章。她也是癫痫症状、癫痫研究、发育医学和儿童神经内科以及欧洲儿童神经内科杂志编辑委员会的成员之一。
“ 当许多变化发生的时候，当在我们有越来越多发现并且能够做得也越来越多的时候，我有幸参与到研究癫痫疾病的工作中。我感到非常荣幸和有幸。” Cross教授表示道。
相关资质
• 儿童癫痫
培训资质:
• 伯明翰大学
• 在伯明翰接受了儿科培训
• 在伦敦获得儿童神经内科博士学位
会员资质:
• 国际抗癫痫联盟儿科委员会主席 (2005 – 2009)
• 欧洲小儿神经学学会助理秘书 (2005 – 2009)
• 英国癫痫研究基金会主席 (2005 – 2011)
• 英国小儿神经内科协会会长 (2008 – 2011)
• 国家健康与护理研究所针对成人与儿童癫痫诊断与管理方面指导方针更新临床顾问 (2009 – 2012)
• 参与负责国际抗癫痫联盟委员会欧洲区事务 (2009 – 2013)
• 国际抗癫痫联盟全球外联工作组小组委员会联合主席 (2009 – 2013)
• 儿科癫痫外科专题组主席 (2001-2013)
• 儿童药物研究网络神经科学临床研究小组的主席
• 国家健康与护理研究所针对癫痫方面指导方针证据更新的主席
• 国际抗癫痫联盟秘书长 (2013-2017)
• Cross教授早期的研究主要是改进成像技术，以确定儿童可能发生患有耐药性局灶性癫痫发作的区域，并基于她的研究开发了一项癫痫手术计划。
• 她最近的研究集中在改善早发性癫痫患儿的治疗效果。
• 认知障碍的检查机制 - 特别是检查睡眠与记忆巩固的关系。
新闻和论文发表
Cross JH. Genetics in the epilepsies - A broadening concept. Eur J Paediatr Neurol. 2020 Jan 10. pii: S1090-3798(20)30010-6. doi: 10.1016/j.ejpn.2020.01.009. [Epub ahead of print]
Shafran R, Bennett S, Coughtrey A, Welch A, Walji F, Cross JH, Heyman I, Sibelli A, Smith J, Ross J, Dalrymple E, Varadkar S; MICE Research Study Team, Moss-Morris R. Optimising Evidence-Based Psychological Treatment for the Mental Health Needs of Children with Epilepsy: Principles and Methods. Clin Child Fam Psychol Rev. 2020 Jan 21. doi: 10.1007/s10567-019-00310-3. [Epub ahead of print].
Specchio N, Pietrafusa N, Cross HJ. Source of cannabinoids: what is available, what is used, and where does it come from? Epileptic Disord. 2020 Jan 1;22(S1):1-9. doi: 10.1684/epd.2019.1121.
Guerrini R, Cross H, Nabbout R, Dalla Bernardina B. Dravet syndrome and other sodium channel-related encephalopathies. Epilepsia 2019 Dec;60 Suppl 3:S1.
Cross JH, Caraballo RH, Nabbout R, Vigevano F, Guerrini R, Lagae L. Dravet syndrome: Treatment options and management of prolonged seizures. Epilepsia 2019 Dec;60 Suppl 3:S39-S48.
Cross JH, Lagae L. The concept of disease modification. Eur J Paediatr Neurol. 2019 Dec 17. pii: S1090-3798(19)30425-8. doi: 10.1016/j.ejpn.2019.12.005. [Epub ahead of print]
Lagae L, Sullivan J, Knupp K, Laux L, Polster T, Nikanorova M, Devinsky O, Cross JH, Guerrini R, Talwar D, Miller I, Farfel G, Galer BS, Gammaitoni A, Mistry A, Morrison G, Lock M, Agarwal A, Lai WW, Ceulemans B; FAiRE DS Study Group. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Lancet 2020 Dec 21;394(10216):2243-2254.
Cross JH, Cock H. A perspective on cannabinoids for treating epilepsy: Do they really change the landscape? Neuropharmacology. 2019 Nov 23:107861. doi: 10.1016/j.neuropharm.2019.107861. [Epub ahead of print] Review.
Auvin S, Avbersek A, Bast T, Chiron C, Guerrini R, Kaminski RM, Lagae L, Muglia P, Cross JH. Drug Development for Rare Paediatric Epilepsies: Current State and Future Directions. Drugs. 2019 Dec;79(18):1917-1935.
Bialer M, Cross H, Hedrich UBS, Lagae L, Lerche H, Loddenkemper T. Novel treatment approaches and pediatric research networks in status epilepticus. Epilepsy Behav. 2019 Dec;101(Pt B):106564. doi: 10.1016/j.yebeh.2019.106564.
van der Louw E, Aldaz V, Harvey J, Roan M, van den Hurk D, Cross JH, Auvin S; Review Group. Optimal clinical management of children receiving ketogenic parenteral nutrition: a clinical practice guide. Dev Med Child Neurol. 2020 Jan;62(1):48-56.
Hargreaves DS, Arora S, Viveiro C, Hale DR, Ward JL, Sherlaw-Johnson C, Viner RM, Dunkley C, Cross JH. Association of quality of paediatric epilepsy care with mortality and unplanned hospital admissions among children and young people with epilepsy in England: a national longitudinal data linkage study. Lancet Child Adolesc Health. 2019 Sep;3(9):627-635.
Pitkänen A, Henshall DC, Cross JH, Guerrini R, Jozwiak S, Kokaia M, Simonato M, Sisodiya S, Mifsud J. Advancing research toward faster diagnosis, better treatment and end of stigma in epilepsy. Epilepsia 2019 Jul;60(7):1281-1292.
Fisher RS, Cross H, D'Souza C, French JA, Haut S, Higurashi N, Hirsch E, Jansen FE, Peltola J, Moshé SL, Perucca E, Lagae L, Roulet-Perez E, Schulze-Bonhage A, Scheffer IE, Somerville E, Sperling MR, Wiebe S, Yacubian EM, Zuberi S. 2017 International League Against Epilepsy classifications of seizures and epilepsy are steps in the right direction. Epilepsia 2019 Jun;60(6):1040-1044.
Cross, J. H., 2015. Children with poor adherence to antiepileptic drugs during the first 6 months of treatment are less likely to be seizure free after 4 years. Evid Based Nurs. 18(2) pp. 54.
Cross, J. H., 2015. Epilepsy (generalised seizures). BMJ clinical evidence.
Cross, J. H., 2015. Seizures associated with hypoglycaemia and subsequent epilepsy. Dev Med Child Neurol. 57(2) pp. 117-118.
Schoeler, N., Cross, J.H., Leu, C., Sander, J.W., & Sisodiya, S., 2014. A genetic basis for response to the ketogenic diet. Epilepsia. 55 pp. 35-36.
Schoeler, N. E., Sander, J. W., Sisodiya, S. M., Cross, H. J., MacDonald, L., Horne, R., & Champion, H., 2014. Assessing parent’s attitudes towards detogenic dietary therapies. Epilepsy and Behavior. 39 pp. 1-5.
Skirrow, C., Cross, J.H., Cormack, F., Harrison, S., Vargha-Khadem, F., Baldeweg, T., 2014. Duration of Temporal Lobe Epilepsy in Children is Associated with Loss of Hippocampal Tissue and Memory Dysfunction. Epilepsia. 55 pp 154-155.
Ryvlin, P., Cross, J.H., Rheims, S., 2014. Epilepsy surgery in children and adults. Lancet Neurol. 13(11) pp. 1114-1126.
Schoeler, N. E., Wood, S., Aldridge, V., Sander, J.W., Cross J.H., Sisodiya, S. M., 2014. Ketogenic dietary therapies for adults with epilepsy: feasibility and classification of response. Epilepsy Behav. 37 pp. 77-81.
Cross, J.H., Auvin, s., Patten, A., Giorgi, L., 2014. Safety and tolerability of zonisamide in paediatric patients with epilepsy. Eur J Paediatr Neurol. 18(6) pp 747-758.
Wilmshurst, J. M., Berg, A. T., Lagae, L., Newton, C. R., Cross, J. H., 2014. The challenges and innovations for therapy in children with epilepsy. Nat Rev Neurol. 10(5) pp. 249-260.
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